WebCancer cells must acquire a greater amount of nutrients, especially glucose. One of the mediators is HIF-1, which increases glucose uptake through the induction of GLUT-1, GLUT-4 and GLUT-1; simultaneosly, it can also be stimulated by TGF-β through the PI3K/AKT/mTOR pathway. Other important mediators are p53 that plays a protective role ... Web22 de mar. de 2007 · Sustained pressure overload induced an accumulation of p53 that inhibited Hif-1 activity and thereby impaired cardiac angiogenesis and systolic function. …
The Interplay Between Tumor Suppressor p53 and Hypoxia …
Web31 de out. de 2024 · In particular, while HIF-1α recruits and shuttles mutant p53 to the DNA genomic elements, mutant p53 does not influence HIF-1 binding to the DNA but impinges on its transcriptional activity. The binding of mutant p53 to the genomic elements is, however, not completely abolished by HIF-1α depletion, indicating that other factors also … Web13 de abr. de 2024 · mdm2蛋白是一种e3泛素连接酶,调节p53的泛素化和降解。 2004年,罗氏公司报告了一种强效的、高选择性的MDM2-p53相互作用的小分子抑制剂。 他们通过筛选合成化合物库确定Nutlin3(38)对MDM2具有高度亲和力(图5)。 tryflex welding cable
Two sequence motifs from HIF-1α bind to the DNA-binding site of p53
Web28 de jul. de 2024 · In mild hypoxia, HIF-1 has a rather protective effect due to the induced expressions of various anti-apoptotic proteins. In contrast, severe hypoxia (anoxia) leads to cell death, which is at least partly caused by HIF-1α-mediated p53 stabilization (Levine, 1997; Suzuki et al., 2001). Role of HIF-1α in Neurodegenerative Diseases Alzheimer’s ... Web30 de nov. de 2024 · Pulmonary fibrosis is a progressively aggravating lethal disease that is a serious public health concern. Although the incidence of this disease is increasing, there is a lack of effective therapies. In recent years, the pathogenesis of pulmonary fibrosis has become a research hotspot. p53 is a tumor suppressor gene with crucial roles in cell … Web25 de jun. de 2024 · It is well known that mutations in P53 can lead to cancer, but it is now also becoming apparent that alterations in P53 can lead to the formation of CAFs. ... (HIF-1α) transcription ... philip webb doncaster east