WebTreatment with an anti-CTGF monoclonal antibody, FG-3019, significantly prolonged survival of mice injected with primary xenograft B-ALL cells when co-treated with conventional chemotherapy (vincristine, L-asparaginase and dexamethasone). Data suggest that CTGF represents a targetable molecular aberration in B-ALL, and blocking CTGF … WebMar 22, 2024 · CTGF Antibody (E-5) is an IgG 2a κ mouse monoclonal CTGF antibody (also designated CCN2 antibody or IGFBP-8 antibody) that detects the CTGF protein of mouse, rat and human origin by WB, IP, IF and ELISA. CTGF Antibody (E-5) is available as both the non-conjugated anti-CTGF antibody form, as well as multiple conjugated forms …
CTGF (D8Z8U) Rabbit mAb Cell Signaling Technology
WebFG-3019 is a fully human monoclonal antibody that interferes with the action of connective tissue growth factor, a central mediator in the pathogenesis of … WebNot for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption. TARGET. ... (50 μg) were separated by 10% SDS-PAGE, and the membrane was blotted with CTGF antibody (GTX124232) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary … fluid in a sentence
Pancreatic Cancer Action Network Partners With FibroGen To …
WebOct 14, 2014 · Clinical trials of anti-CTGF antibodies in idiopathic pulmonary fibrosis and pancreatic cancer have been initiated. 51,52,53,54,55,56. In cardiovascular models, the role of CTGF is still highly ... WebJun 6, 2012 · A monoclonal antibody to CTGF that is currently in clinical development (FG-3019) has demonstrated the ability to reverse vascular stiffening and improve cardiac function in a rat model of diabetic complications. FG-3019 has also exhibited activity in a murine radiation-induced pulmonary fibrosis model. WebFG-3019 is a fully human monoclonal antibody specific for CTGF. Pre-clinical studies suggest that FG-3019 penetrates into tissues to reduce effective tissue levels of CTGF … fluid in air sacs treatment