Chromosome substitution strains

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August undefined, 2024

WebJun 12, 2006 · An analysis of transcriptional variation in the liver using a panel of B.A chromosome substitution strains identified 4209 transcripts that are differentially expressed relative to the C57BL/6J background and 1010 transcripts that are differentially expressed between C57BL/6J and A/J strains. A subset of these strains (substituting … WebSep 29, 2024 · Analyzing metabolic traits and gene expression levels in the offspring of a series of crosses between mouse chromosome substitution strains demonstrated that inter-chromosomal epistasis was a dominant feature of these complex traits. Epistasis typically accounted for a larger proportion of the heritable effects than those due solely to …

Chromosome Substitution Strain - an overview

WebDec 1, 2003 · Chromosome substitution strains (CSSs) are important in this resource portfolio because of their demonstrated use for gene discovery, genetic and epigenetic studies, functional characterizations ... WebChromosome substitution strains (CSSs) are important in this resource portfolio because of their demonstrated use for gene discovery, genetic and epigenetic … great harvest bakery cafe midlothian

The importance of understanding substrains in the genomic age

WebFeb 3, 2010 · Discovery of genes that confer resistance to diseases such as diet-induced obesity could have tremendous therapeutic impact. We previously demonstrated that the C57BL/6J-ChrA/J/NaJ panel of chromosome substitution strains (CSSs) is a unique model for studying resistance to diet-induced obesity. In the present study, three … http://informatics.jax.org/nomen/strains.shtml WebJan 1, 2007 · By partitioning the genome into a panel of new inbred strains with single chromosome substitutions, one strain for each of the autosomes, the X and Y chromosome, and the mitochondria,... fll to pittsburgh

Chromosome substitution strains: Gene discovery, functional analysis ...

WebDec 16, 2008 · Chromosome substitution strains (CSSs) enable statistically powerful studies based on testing engineered inbred strains that have single, unique, and … WebJan 1, 2007 · By partitioning the genome into a panel of new inbred strains with single chromosome substitutions, one strain for each of the autosomes, the X and Y chromosome, and the mitochondria,... fll to port of miami transfersWebGenetic crosses and chromosome substitution experiments conclusively showed that the expression of both genes (located on the 2R chromosome) is repressed by factors on the third chromosome of the insecticide-susceptible 91C and rosy 506 strains. In contrast, the third chromosome of the MHIII-D23 and 91R strains carries a loss-of-function ... great harvest bakery cafe tyler

"WebChromosome substitution strains QTL mapping can be accelerated using chromosome substitution strains (CSSs), which enable the first two steps above to be omitted. We … " - Chromosome substitution strains

Chromosome substitution strains

WebGenetic crosses and chromosome substitution experiments conclusively showed that the expression of both genes (located on the 2R chromosome) is repressed by factors on the third chromosome of the insecticide-susceptible 91C and rosy506 strains.

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WebA chromosome substitution strain (CSS) is an inbred strain in which one chromosome has been substituted from a different inbred strain by repeated backcrossing. A complete CSS set has one strain representing each chromosome against a uniform background, thus allowing genome-wide scans to be carried out for quantitative trait loci (QTLs) … WebGenetic resistance to diet-induced obesity in chromosome substitution strains of mice.pdf. 2011-11-03 ...

WebApr 16, 2004 · Chromosome substitution strains (CSSs) have been proposed as a simple and powerful way to identify quantitative trait loci (QTLs) affecting developmental, … WebFeb 1, 2006 · (3) Chromosome substitution strains (CSS) Chromosome substitution strains (CSS) are mice strains with one single chromosome replaced by the corresponding chromosome from a donor strain...

WebJAX® Mice substrains were used to generate panels of consomic (chromosome substitution) strains for use as gene mapping tools 21. The Complex Trait Consortium (www.complextrait.org) plans to use JAX® Mice substrains as progenitor strains for the generation of >500 recombinant inbred strains 22. WebJul 8, 2003 · A chromosome substitution strain (CSS) is an inbred strain in which one chromosome has been substi-tuted from a different inbred strain by repeated backcrossing. A complete CSS set has one strain representing each chromosome against a uniform background, thus allowing genome-wide scans to be carried out for …

WebRecombinant inbred (RI) and chromosome substitution (CS) strain panels Many common inherited human diseases — such as diabetes, cardiovascular disease, obesity, …

WebA chromosome substitution strain (CSS) or consomic strain is an inbred strain in which a single chromosome from a donor strain replaces the corresponding chromosome in … great harvest bakery cafe midlothian vaWebChromosome substitution strains (CSS) were originally obtained as a gift from Dr. Joseph Nadeau (Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106). Each CSS is a homozygous inbred strain that is C57BL/6J with one chromosome pair from A/J. great harvest bakery cedar rapidsWebChromosome substitution strains (CSSs) are based on a different paradigm that deal with the signal-noise problem in a novel way ( 20 ). Each CSSs is an inbred strain that differs from the host strain by a single intact and homozygous chromosome on a defined and uniform genetic background. fll to pittsburgh flightsWebChromosome substitution strains QTL mapping can be accelerated using chromosome substitution strains (CSSs), which enable the first two steps above to be omitted. We propose replacing the name... fll to port everglades transportationWebChromosome Substitution Strains: A New Way to Study Genetically Complex Traits Article Full-text available Feb 2006 Annie E Hill-Baskin Eric S Lander Joseph H Nadeau Many biological traits and... fll to port of miami transportationWebMay 23, 2024 · chromosome substitution The replacement of one or more chromosomes by others (totally or partially homologous) from another source (either a different strain of the same species or a related species that will permit hybridization) by a suitable crossing programme. A Dictionary of Zoology MICHAEL ALLABY fll to pls southwestWebA chromosome substitution strain (CSS) or consomic strain is an inbred strain in which a single chromosome from a donor strain replaces the corresponding chromosome in the host/parental strain on a defined and uniform genetic background. From:Handbook of Behavioral Neuroscience, 2016 Related terms: Phenotype Mutation Quantitative Trait Locus great harvest bakery cary nc